PECAM-1 is a critical mediator of atherosclerosis

PECAM-1 is a critical mediator of atherosclerosis.

Atherosclerosis is a chronic inflammatory disease of large arteries in which lesion development preferentially occurs at vessel sites exposed to rapid changes in flow. We have previously shown that platelet endothelial cell adhesion molecule (PECAM-1), a surface receptor of the immunoglobulin superfamily, is involved in mechanosensing of rapid changes in flow. We wondered whether apolipoprotein...

VCAM-1 is critical in atherosclerosis.

is an immunoglobulin-like adhesion molecule expressed on activated endothelial cells (1). VCAM-1 binds to α 4 β 1 integrin, which is consti-tutively expressed on lymphocytes, monocytes, and eosinophils. Interestingly , VCAM-1 can mediate both rolling-type adhesion and firm adhesion , depending on the avidity status of α 4 β 1 integrin (2). Although it is structurally similar to ICAM-1 and other...

IDO2 Is a Critical Mediator of Autoantibody

PECAM-1-dependent neutrophil transmigration is independent of monolayer PECAM-1 signaling or localization.

Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31), a tyrosine phosphoprotein highly expressed on endothelial cells and leukocytes, is an important component in the regulation of neutrophil transendothelial migration. Engagement of endothelial PECAM-1 activates tyrosine phosphorylation events and evokes prolonged calcium transients, while homophilic engagement of neutrophil PECAM-1 ac...

Bcl-2 is a critical mediator of intestinal transformation.

Intestinal tumour formation is generally thought to occur following mutational events in the stem cell pool. However, active NF-κB signalling additionally facilitates malignant transformation of differentiated cells. We hypothesized that genes shared between NF-κB and intestinal stem cell (ISCs) signatures might identify common pathways that are required for malignant growth. Here, we find that...